|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|
31810917 |
2019 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|
31810917 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Matrix Metalloproteinase-9 rs3918242 Promoter Genotypes With Colorectal Cancer Risk.
|
31810917 |
2019 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The rs3918242 polymorphism may be a susceptible predictor of susceptibility of IS.
|
31415895 |
2020 |
|
Large-artery atherosclerosis (embolus/thrombosis)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analysis by the subtypes of IS showed that the rs3918242 polymorphism was significantly correlated with the risk of patients with large artery atherosclerosis.
|
31415895 |
2020 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D deficiency was also a predominant feature among all MS patients irrespective of their MMP9 genotypes of rs3918242, implying its association with MS activity in different courses of the disease.
|
31082619 |
2019 |
|
Mitral Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D deficiency was also a predominant feature among all MS patients irrespective of their MMP9 genotypes of rs3918242, implying its association with MS activity in different courses of the disease.
|
31082619 |
2019 |
|
Vitamin D Deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D deficiency was also a predominant feature among all MS patients irrespective of their MMP9 genotypes of rs3918242, implying its association with MS activity in different courses of the disease.
|
31082619 |
2019 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, we found no significant association between -1562 C > T, rs3918242 polymorphism, and asthma susceptibility in any of the genetic model comparisons.
|
30931075 |
2019 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, publically available data indicate that rs3918242 genotype is related not to MMP9 expression, but rather to expression of SLC12A5, a nearby gene coding for a K+/Cl- cotransporter, whose expression has also been related to schizophrenia.
|
30668668 |
2019 |
|
Spider nevus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotypes of rs243865 and rs3918242 polymorphisms had remarkable correlations with spider nevi, clubbed fingers (toes), transaminase elevation, portal vein width, esophageal varices, Child-Pugh classification and partial pressure of arterial oxygen (PaO<sub>2</sub>).
|
30392570 |
2018 |
|
Hantavirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
CC/CT genotype and C allele of MMP-2 rs243865 polymorphism as well as CC/TT genotype and T allele of MMP-9 rs3918242 polymorphism increased the risk of HPS in cirrhotic patients.
|
30392570 |
2018 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study provides preliminary evidence that the MMP9 rs3918242 polymorphism is linked to a higher risk of IS, confirming the role of MMP9 in the pathophysiology of IS, with potentially important therapeutic implications.
|
30257242 |
2018 |
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Subgroup analysis by the type of stroke showed that MMP-9 gene rs3918242 polymorphism increased the risk of ischemic stroke.
|
30132967 |
2018 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis by the type of st</span>roke showed that MMP-9 gene rs3918242</span> polymorphism increased the risk of ischemic stroke.
|
30132967 |
2018 |
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant in MMP-9 -1562 C/T (single nucleotide polymorphisms labeled rs3918242) has been extensively evaluated as predisposing factors to digestive cancers susceptibility.
|
29890308 |
2018 |
|
Subarachnoid Hemorrhage
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study showed that the rs3918242 (T) and rs17576 (G), the cross reaction between rs3918242 and smoking increased the risk of subarachnoid hemorrhage.
|
29763368 |
2018 |
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs.
|
29739236 |
2019 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
A statistically significant association between rs3918242 polymorphism and CAD was observed in allelic model (Odds ratio (OR) 1.34; 95% confidence interval (CI) 1.20-1.50; <i>p</i> < 0.00001), recessive model (OR 1.43; 95% CI 1.17-1.75; <i>p</i> = 0.0004), and in dominant model ( OR 1.36; 95% CI 1.20-1.53; <i>p</i> < 0.00001).
|
29507703 |
2018 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, we also found that there is a statistically significant association between rs3918242 polymorphism and myocardial infarction (MI) in Asians with allelic model (OR 1.66; 95% CI 1.29-2.14; <i>p</i> < 0.0001), recessive model (OR 2.29; 95% CI 1.44-3.63; <i>p</i> = 0.004), and dominant (OR 1.74; 95% CI 1.29-2.35; <i>p</i> = 0.0003) model.
|
29507703 |
2018 |
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, we performed two meta-analyses for MMP9 rs3918242 polymorphism in endometriosis/adenomyosis and preeclampsia but found no association with either disorder.
|
29309889 |
2018 |
|
Endometriosis of uterus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, we performed two meta-analyses for MMP9 rs3918242 polymorphism in endometriosis/adenomyosis and preeclampsia but found no association with either disorder.
|
29309889 |
2018 |
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the human homologues of these genes were significantly associated with susceptibility for anxiety disorders (MMP9: rs3918242 and BDNF: rs6265, rs10835210 and rs11030107).
|
29288745 |
2018 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer.
|
28980922 |
2017 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion.
|
28980922 |
2017 |